Cannazo | Pain Aid External

Mechanism of action of active ingredient:
● Medical Cannabis exerts its action via two vital and active components, cannabidiol
(CBD) and delta-9-tetrahydrocannabinol (THC). THC,one of the active ingredients in
cannabis, activates cannabinoid receptors type 1 and 2 i.e CB1 and CB2 receptors (1-2).
● 2-arachidonoyl-sn-glycerol (2-AG), anandamide and endocannabinoids are produced in
injured tissues via distinct biochemical pathways that are known to suppress sensitization
and inflammation by activation of cannabinoid (CB) receptors (3-5).
● The compounds in Vijaya ultimately attach to cannabinoid receptors in the brain when
someone drinks it. These receptors have the ability to alter mental equilibrium and
produce euphoric effects. Some persons experience a decrease in depression symptoms as
a result of this change (5).
● CBD and THC, reduce pain at the site of injury.The anti-inflammatory properties of
THCs are primarily driven via activation of CB2 receptors on immune cells which
ultimately dampens the body’s pain-inducing response to injury. Whereas, CBD reduces
inflammation via blocking inflammatory mediators & shifting the activation of
macrophage repair cells from the pro-inflammatory type to the anti-inflammatory type
(6-9).
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